A study published in The New England Journal of Medicine confirms that interleukin 10 is the most important immunomodulatory cytokines in the intestine. Furthermore, it has been shown that mutations in the gene that encodes some of its proteins in patients with early stages of inflammatory bowel disease.
Patients in the early stages of enter colitis have mutations in the genes encoding protein subunits of IL-10R, which implies an immune response in the intestine hyper inflammatory. The stem cell transplant achieved a remission in a patient, according to results of a study to advance the New England Journal of Medicine.
The group of Christoph Klein, Department of Pediatric Hematology and Oncology College of Medicine in London, has conducted an analysis of genetic relationship and sequencing of candidate genes of two unrelated consanguineous families. Furthermore, this equipment is studied in six additional patients with the early stages of inflammatory bowel disease mutations in two genes candidates who conducted functional analysis of peripheral blood cells mononuclear. (more…)
